Which medication is considered first-line analgesia for mild to moderate pediatric pain?

• A. Ibuprofen
• B. Diphenhydramine
• C. Acetaminophen
• D. Morphine

Answer: (C)

For mild to moderate pain in children, the first-line choice should provide reliable relief with the lowest risk of significant side effects. Acetaminophen fits this role well because it effectively reduces pain and fever while having a favorable safety profile in most pediatric patients. It does not irritate the stomach or affect platelet function the way NSAIDs can, and it avoids the risks of sedation or respiratory depression associated with opioids. Diphenhydramine isn’t an analgesic at all, so it doesn’t address pain. Morphine is an opioid suitable for more severe pain and carries higher risks, making it inappropriate as a first-line option for mild to moderate pain. If inflammation is a key component of the pain or if acetaminophen is not suitable, an NSAID like ibuprofen can be considered, but acetaminophen is typically the preferred initial analgesic due to its safety profile in most pediatric cases.